Understanding Alzheimer’s in Adults with Intellectual and Developmental Disabilities

By Katie Fahrenbruch, Director of Community Engagement, Alzheimer’s Association Florida Chapters

According to the National Down Syndrome Society, about 30% of people with Down syndrome who are in their 50s have Alzheimer’s dementia. Approximately 50% of people with Down syndrome in their 60s have Alzheimer’s dementia. In the general population, that number is significantly less; as little as 11% of U.S. adults age 65 and older. 

Where does the elevated risk come from? 

1. Genetic Factors: Individuals with Down syndrome have an extra copy of chromosome 21. This leads to overproduction of amyloid precursor protein, contributing to the development of amyloid plaques in the brain, a hallmark of Alzheimer’s disease.

2. Biological Changes: People with Down syndrome often experience earlier onset of brain changes related to Alzheimer’s, typically starting in their 40s, compared to the general population.

3. Health Factors: Other health issues common in individuals with Down syndrome, such as thyroid problems or obesity, may also contribute to the increased risk.

Importance of Early Diagnosis and Care

Given the high risk, early diagnosis and quality care are crucial for individuals with Down syndrome. For people with intellectual and developmental disabilities (IDD) that do not have Down syndrome, the risk of developing diseases like Alzheimer’s is similar to that of the general public. In both of these populations, recognizing the signs of Alzheimer’s early can lead to timely interventions that may help manage symptoms and improve quality of life.

Resources and Support

The Florida chapters of the Alzheimer’s Association are hosting diagnostic and quality care summits to provide valuable information and resources. These events are designed to help families and providers understand the disease, manage symptoms and access necessary resources.

Three events across Florida – Jacksonville, Orlando and Sunrise – will be available to attend in person or virtually. Guest speakers include Drs. Heather Snyder and Brian Chicoine along with a local family and IDD service provider. 

Find a conference near you and register today.